developed a technique based on the Kullback-Leibler measure to identify and segment the midsagittal plane. used parameterized surface matching to automatically extract the midsagittal plane from a sequence of MRI slices, to allow morphometric measurements to be more easily obtained. Obtaining the midsagittal plane slice using these criteria allows morphometric measurements from different individuals to be compared and analyzed. The midsagittal plane is identified using a set of criteria, specifically visibility, or clear definition of four structures: the genu of the corpus callosum, the splenium of the corpus callosum, the infundibulum, and the cerebral aqueduct. Typically, morphometric measurements are obtained from an image of the median plane of the head, known as the midsagittal plane shown in Fig 1.

revealed the use of morphometric measurements in diagnosing Alzheimer’s disease, which further highlights morphometric measurements as a potential diagnostic tool for various neurological conditions.

They found that McRae’s line and basion to posterior axial line were significantly different in cases with certain prevalent conditions than those without such conditions. illustrated the significance of morphometric measurements to identify prevalent conditions related to CMI morphometrics. One area of CMI research involves morphometric measurements evaluated on structural magnetic resonance images (MRI). The current diagnosis process utilizes imaging of the cerebellar tonsils, patient-reported symptoms, and neurological signs. CMI patients experience a range of symptoms, including headaches, retro-orbital pain, ocular disturbances, cough-associated headache, neck pain, cognitive dysfunction, depression, anxiety, balance problems, and numbness. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ĭhiari malformation type I (CMI) is a neurological condition characterized by cerebellar tonsils that extend below the foramen magnum at the base of the skull.

1R15NS109957-01A1), for funding this research work, granted to FL. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: The authors would like to thank Conquer Chiari and the National Institutes of Health, NINDS R15 (Grant No. Received: ApAccepted: JPublished: August 10, 2022Ĭopyright: © 2022 Morkos et al. PLoS ONE 17(8):Įditor: Yangming Ou, Harvard Medical School, UNITED STATES (2022) The importance of precise plane selection for female adult Chiari Type I malformation midsagittal morphometrics. Citation: Morkos M, Eppelheimer M, Nwotchouang BST, Ebrahimzadeh SA, Bhadelia RA, Loth D, et al.

Conquer chiari symptoms